SIRT1 activated by AROS sensitizes glioma cells to ferroptosis via induction of NAD+ depletion-dependent activation of ATF3
Ferroptosis is a type of programmed cell death resulting from iron overload-dependent lipid peroxidation, 9021 glow and could be promoted by activating transcription factor 3 (ATF3).SIRT1 is an enzyme accounting for removing acetylated lysine residues from target proteins by consuming NAD+, but its role remains elusive in ferroptosis and activating